Product Description: In this volume are contributions based on a meeting arranged by the WHO and the Fondation IPSEN. The scientists focus on neurodegenerative disorders like Alzheimer's Disease, Chromosome 17-Linked Dementia, Parkinson's Disease and disorders with tauopathies.

Four chapters represent the intense current effort to understand the way in which the mitochondrion controls the activation of the final stages of cell death. Another four articles attack the problem from the other side. How do specific insults in particular human or mouse neuro-degenerative diseases translate into mechanisms that will not only allow us to better understand what is happening in these patients but also, with luck, allow for development of more efficient and specific drugs in the future? Firstly, the concept of a central common cell death pathway, originally derived from studies on the nematode, has been an outstanding productive paradigm in bringing together different strands of research. Secondly, truly striking links have been made between results obtained in the culture dish (or even cell-free systems) and the diseased human brain.

Product Description: The evolutionary approach presented in this book provides clues to the relevance of social interactions as part of the natural selection process, for the survival of species, including ours. Proceeding further, as science often does, from the simple to the complex, and taking advantage of the wide pluridisciplinary range of the participants – coming from fields as diverse as molecular neuroscience, anthropology and psychology – a final question was raised as to whether biological substrates of complex social behaviors may also be relevant to moral issues characteristic of humans beings (Hauser and Young 2008): for instance, information aiming at decision making is not processed by the brain in the same way, whether or not a given situation is perceived as involving moral dilemmas...read more

Product Description: This volume surveys the recent advances and provides an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. Current and future avenues are discussed by distinguished scientists...read more

Product Description: This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease...read more

Product Description: Man has been pondering for centuries over the basis of his own ethical and aesthetic values. Until recent times, such issues were primarily fed by the thinking of philosophers, moralists and theologists, or by the findings of historians or sociologists relating to universality or variations in these values within various populations...read more

Product Description: Understanding the relationship between frailty and longevity becomes increasingly important as the world continues to age and life expectancy in most countries continues to increase. The articles contained in this book are the outcome of a colloquium sponsored by Fondation IPSEN in which interdisciplinary perspectives were brought to bear on conceptual, empirical and clinical aspects of this relationship...read more

Product Description: From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer's Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas...read more

Product Description: At the beginning of the 20th century, life expectancy at birth in North America and Western Europe was around 50 years of age. Nowadays, women have gained more than 30 years of age and men are trailing closer. However, according to several sociologists, such as Louis Chauvel, the notion of a 'greying society' is not entirely adequate since aging people are physically and socially younger and more active for a longer time...read more

Product Description: In mammals, a robust physiologic system acts to maintain relative constancy of weight. A key element of this system is leptin. The nature of this "brain-somatic" cross talk is as yet poorly understood, but it is likely to have important implications for the pathophysiology and treatment of obesity, diabetes and other metabolic disorders...read more

Product Description: Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms...read more (view table of contents, read Amazon.com's description)

Product Description: This book presents reviews on recent developments in human genome research and their possible application to the prevention and control of noncommunicable diseases. The progress made in understanding the etiology and pathogenesis of a number of diseases of later life, e...read more

Product Description: Hardbound.

Product Description: Temporal coding in the brain documents a revolution now occurring in the neurosciences. How does parallel processing of information bind together the complex nature of the outer and our inner worlds? Do intrinsic oscillations and transient cooperative states of neurons represent the physiological basis of cognitive and motor functions of the brain? Some answers to these challenging issues are provided in this book by leading world experts of brain function...read more

Product Description: University of Melbourne, Victoria, Australia. Proceedings of the Ninth Colloque Medecine et Recherche, held in Lyon, France, June 21, 1993. Advanced Alzheimer's research.

Product Description: College de France, Paris. Research and Perspectives in Neurosciences Series. Proceedings of the third Colloques Medecine et Recherche organized by the Foundation IPSEN and held in Paris, France, on November 24, 1992. Advanced neurological and behavioral research...read more

Product Description: Paperback. On April 20, 1991, the first international meeting on EGb 761 at Montreux, Switzerland, evaluated the cerebral protective effects of this drug. To increase our knowledge of EGb 761 and to review and discuss its place in protection against free-radical-induced disorders, an international conference of chemists, biochemists, biophysicists and clinicians was held in Budapest (June 12, 1992)...read more

Product Description: The term "Alzheimer's disease" is currently used to refer to senile and also presenile dementia, but the heterogeneity of this disorder is demonstrated in many of its aspects. This is of great theoretical interest, and with the appearance of new therapeutic interventions, it may well also start to have very significant practical importance...read more

Product Description: There is an increasing body of literature suggesting that at some stage during the development of most human diseases free radicals may be involved,and therefore retarded by antioxidants. Although in some cases this evidenceis only circumstantial, it is becoming overwhelming...read more

Product Description: Paperback. This volume contains the Proceedings of the International Symposium on Falls in the Elderly convened under the auspices of the IPSEN Institute, in Madrid, during the Second European Congress of Gerontology (10 September 1991)...read more

Product Description: The relationship between body (or brain) and mind is still poorly understood. Alzheimer's disease could be a good model for the study of typical neurophilosophical problems such as the mind brain relationship and also, more particularly, as a means to understanding different aspects of human consciousness and thinking, since Alzheimer's disease presents a situation in which both modification of the cognitive faculties and organic changes, cellular and even molecular, may be observed simultaneously...read more

Product Description: The use of modern genetic techniques has resulted in the identification of polymorphic markers that are involved in the normal regulation and function of the cardiovascular system. Many of these genes may contribute to the individual differences in the risk of developing coronary heart disease and hypertension...read more

Product Description: This book, the first in the new series RESEARCH AND PERSPECTIVES IN NEUROSCIENCE, contains the proceedings of the meeting which was held in Paris on September 24, 1990. Like the meetings on Alzheimer's disease, this series will deal with the most current research...read more

Product Description: The dramatic developments in molecular genetics have brought up new ethical challenges. This book presents the discus- sions which emerged from a joint meeting of the Foundation IPSEN and the WHO in Brno, close to the monastery where Gregor Mendel founded the science of genetics, where a number of molecular geneticists, psychiatrists, churchmen, and legal professionals metto consider just these topics...read more