Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event, ""Alzheimer 100 Years and Beyond"" organized on the initiation of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, was the highlight of the Year of Alzheimer. However, beyond these few months of tributes, the centennial offers a unique opportunity to assess both the progress achieved and the uncertainties remaining. This volume, a collection comprised mainly of articles by the invited speakers and also of a few other prominent researchers, is meant to be a record of those events.

Product Description: The discovery of microRNAs has revealed an unexpected and spectacular additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain...read more

Product Description: This volume brings together experts from basic and clinical science to provide a broad survey of the role of insulin in the brain, and to discuss the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease...read more

Product Description: Growth is a complex process that is essential to life. Not only does size play an important role in the process of cellular proliferation, but body size is also a critical factor in determining which organisms live longer. Evolution has been characterised by a dramatic increase in an organism’s body size, which is not only limited to the size of the brain...read more

Product Description: Peripheral hormones have a major impact on the brain: they are able to interfere with its development, to affect release of neurotransmitters and concentrations of receptors, to trigger growth factors involved in lesion repair. These multiple actions account for their capacity to modulate a number of physiological parameters, from reproductive functions to memory, behaviour and aging...read more

Product Description: Promising effects in mice of immunization by ß-amyloid stimulated substantial research efforts and high hopes. In retrospect, this study appears simultaneously logical, consistent as it is with the amyloid theory central today in the field of Alzheimer's disease studies, and paradoxical, because it involved using the toxic substance itself for a treatment benefit...read more

Product Description: In this new volume in the series Research and Perspectives in Neurosciences the authors have presented and discussed their findings in the fields of speech and language disorders, X-linked mental retardation, gene therapy in the CNS, memory and learning disorders and other fields...read more

Product Description: In this third volume on longevity Fondation Ipsen has again collected the most recent results in research on genes and diet in the evolution of human longevity, educational level and longevity, cognitive impairment and survival at older age and other contributions...read more

Product Description: The only way we can convey our thoughts in detail to another person is through verbal language. Does this imply that our thoughts ultimately rely on words? Is there only one way in which thoughts can occur? This ambitious book takes the contrary position, arguing that many possible "languages of thought" play different roles in the life of the mind...read more

Product Description: The main message from this book is that the different protein aggregation processes may all be amenable to a small number of intervention steps based on a common theme of the modulation of production, turnover and deposition of the corresponding disease gene products...read more

Product Description: The advances in human genetics that have ocurred during the past 20 years have revolutionized our knowledge of the role played by inheritance in health and disase. It is clear that our DNA determines not only the emergence of catastrophic single-gene disorders, which affect millions of persons worldwide, but also interacts with environments to predispose individuals to cancer, allergy, hypertension, heart disease, diabetes, psychiatric disorders and even to some infectious diseases...read more (view table of contents, read Amazon.com's description)

Product Description: This is the latest volume in the series Research and Perspectives in Neurosciences. Fondation IPSEN has again collected superb contributions to the fields neuro-immune, neurodegenerative and psychiatric disorders. (view table of contents, read Amazon.com's description)

Product Description: The book series in which this volume by Mayeux and Christen has been published represents always the latest results of well-known scientists in the field of Alzheimer's disease research. In this volume different aspects from costs, risk factors, genes, drugs to prevention are dealt with...read more (view table of contents, read Amazon.com's description)

Product Description: Over the last twenty years there has been an explosive growth in our understanding of the molecular, cellular, and anatomical changes that occur in the days and weeks following brain injury. It is now clear that training and exposure to certain environments can modify and shape neuronal plasticity in lower animals and humans...read more (view table of contents, read Amazon.com's description)

Product Description: With the discovery of the presenilin genes, molecular and biochemical studies of Alzheimer's disease have recently undergone a major revolution. One of the greatest revelations to arise from these studies of the presenilins is the findings that, like the familial Alzheimer's disease mutations in APP, the mutations in the presenilin genes lead to increased production and secretion of the longer form of the Aß peptide, Aß42, which seeds ß-amyloid formation in the brain...read more (view table of contents, read Amazon.com's description)

Product Description: Massachusetts General Hospital, Boston. Proceedings of a conference exploring the relationship between the neuropathological lesions of Alzheimer's Disease and the underlying causes. 53 contributors, 28 US. (view table of contents, read Amazon.com's description)

Product Description: The contributions to this book, the seventh in the series, deal with cell proliferation prior to neuronal migration, cellular and molecular factors characteristic of neuronal migration, and with postmigrational neuronal and axonal plasticity...read more (view table of contents, read Amazon.com's description)

Product Description: Understanding the developmental origin of the nervous system is important for two reasons. First, it is intellectually interesting as an example of the assembly of a multicellular system. Second, this knowledge will permit us to control the assembly and disassembly of this system in health and disease...read more (view table of contents, read Amazon.com's description)

Product Description: There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age...read more

Product Description: Neuroscience has paid only little attention to decision-making for many years. Although no field of science has cohered around this topic, a variety of researchers in different areas of neuroscience ranging from cellular physiology to neuropsychology and computational neuroscience have been engaged in working on this issue...read more

Product Description: Gene transfer technology is a powerful tool for increasing our understandingof brain functions. It is also the basis of gene therapy, which is now technically possible for the correction of many human diseases, including several disorders of the nervous (and muscular) system such as Alzheimer's disease, Parkinson's disease, and dystrophy...read more